Principles of human teratology: drug, chemical, and infectious exposure.
نویسنده
چکیده
OBJECTIVE To provide a teratology update for prescription and non-prescription drugs and infections during pregnancy. OPTIONS Limited to teratology principles and possible common exposures during pregnancy. EVIDENCE A search of Medline and textbooks was conducted for information published to June 2006 on teratology exposure risks. This document represents an abstraction of the information. BENEFITS, HARMS, AND COSTS This consensus provides practitioners with a summary of information regarding teratology risks for drug, chemical, and infection exposures during pregnancy.
منابع مشابه
Teratogens and teratogenesis: general principles of clinical teratology.
Numerous factors hinder our ability to recognize fully human teratogens. Among these are the limitations of animal and epidemiologic studies, the lack of understanding of the mechanisms of action of most teratogens, and the variability in expression of the clinical manifestation. Dose and timing of exposure, interactions with other environmental agents, and host susceptibility influence this va...
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James Graves Wilson's six principles of teratology [4], published in 1959, guide research on teratogenic agents and their effects on developing organisms. Wilson's six principles were inspired by Gabriel Madeleine Camille Dareste's five principles of experimental teratology [4] published in 1877. Teratology is the study of birth defects [5], and a teratogen is something that either induces or a...
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Mercury and its compounds have a wide spectrum of toxicities depending upon the chemical forms and modes of exposure. Among the various chemical forms, mercury vapor and methylmercury are well known and established as neurotoxic agents. Since the disasters in Minamata and Iraq, in which fetuses were more susceptible than adults to methylmercury exposure, much attention has been focused on prena...
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The potential of many drugs and chemicals to cause prenatal harm is well-established. The types of effects seen vary and include spontaneous abortions, stillbirths, congenital malformations present at birth, and conditions detected only months to years after birth. Most studies designed to determine whether agents cause malformations have examined the effects of exposure of the embryo or fetus ...
متن کامل"Experimental Studies on Congenital Malformations" (1959), by James G. Wilson
The article "Experimental Studies on Congenital Malformations" was published in the Journal of Chronic Diseases in 1959. The author, James G. Wilson, studied embryos and birth defects [3] at the University of Florida Medical School in Gainesville, Florida. In his article, Wilson reviewed experiments on birds [4] and mammals from the previous forty years to provide general principles and guideli...
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ورودعنوان ژورنال:
- Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
دوره 29 11 شماره
صفحات -
تاریخ انتشار 2007